By J. C. Frölich (auth.), Peter W. Ramwell (eds.)

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65-80, Raven Press, New York. Frolich, J. , Hollifield, J. , Dormois, J. , Seyberth, H. , Michelakis, A. , and Oates, J. , 1976b, Suppression of plasma renin activity by indomethacin in man, eirc. Res. (in press). Gill, J. , Frolich, J. , Bowden, R. , Taylor, A. , Keiser, H. , Seyberth, H. , Oates, J. , and Bartter, F. , 1976, Bartter's syndrome: A disorder characterized by high urinary prostaglandins and a dependence ofhyperreninemia on prostaglandin synthesis, Am. 1. Med. 61:43-51. Gohlke, R.

Covino, B. , Takman, H. , and Smith, E. , 1965, Renomedullary vasodepressor substance medullin: Isolation, chemical characterization, and physiological properties, eire. Res. 17:57. Lee, J. , Takrnan. B. H .. Atrep, K. , and Gougoutas, J. , 1%7, The identification of prostaglandin E2 , F2n , and A2 from rabbit kidney medulla, Biochem. 1. 105: 1251. Lee, J. , McGiff, J. , Aykent. , Mudd, J. , and Frawley, T. , 1971. Prostaglandin A" antihypertensive and renal effects: Studies in patients with essential hypertension.

1972, Radioimmunoassay of the A prostaglandins, Prostaglandins 2:41. Zusman, R. , Caldwell, B. , and Mulrow, P. , 1973a, The effect of chronic sodium loading and sodium restriction on plasma prostaglandin A, E, and F concentrations in normal humans, J. CUn. Invest. 52:1093. Zusman, R. , 1973b, Antihypertensive function of a renal-cell carcinoma, New Engl. J. Med. 290:843. NOTE ADDED IN PROOF The initial investment necessary to obtain a mass spectrometer useful for prostaglandin analysis used to be in excess of $120,000, making it affordable for only a few laboratories.

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