By Arlene J. Klotzko

A distinct number of papers by means of best scientists and bioethicists at the technology and social matters with regards to large-animal cloning. The e-book info the potential clinical advantages for improvement of prescription drugs in transgenic animals and of organs for xenotransplants, and the results for the potential for human cloning. It presents an intensive, authoritative evaluation and clarification of what has been performed, together with contemporary animal cloning, and what the probabilities are for this new interesting technological know-how.

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A J K: Was the cloning of Dolly a kind of midlevel goal in your quest to clone transgenic sheep? Please explain how she fits into the larger intellectual and research scheme. G B: Creating Polly was our true goal. And it was Megan and Morag who were our halfway house to doing genetic modification. We are likely to be using fetal fibroblasts to do Polly-type experiments in the future. In a way, Dolly was a sort of detour—using adult cells. But using adult cells is more likely to be useful in animal breeding.

At the present time, we think it will be more likely that we could successfully use the technique with fetal cells because you already have enough when you start. ] If you start with an embryo, you have so few [cells] that you lose a large part of that opportunity in just growing up to a minimum number of cells necessary for gene targeting. So that by the time you have gone from the few thousand cells that you started with up to the number that you need for gene targeting, you no longer have enough time in culture during which the cells will remain normal to allow you to carry on.

CLONING: THE SOCIAL AND REGULATORY ISSUES A J K: Can science be regulated? If so, how? Must we wait until the discoveries are made before we decide how—or, indeed, whether—to allow them to be implemented? G B: Yes, of course, we can regulate science. But it is quite difficult to do it before the fact. The Asilomar Conference on genetic modification was an attempt to do that. We ourselves have had similar efforts in this country on this subject, as you have in the United States. There can be a general, very broad law and, within that, an organization that judges the experiments.

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