By John Lynn and Stephen R Bloom (Eds.)
A reference textual content at the surgical features of endocrine affliction drawing at the services of surgeons, physiologists, radiologists and expert endocrinologists. every one endocrine gland is roofed in different chapters outlining its body structure, pahtology, imaging and surgical administration
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IGFBP-3, the largest of these molecules, binds the majority of circulating IGFs, the complex being retained within the circulation and levels are related to growth hormone status . The mechanisms by which IGFs are bound to the binding proteins and how and under what circumstances they are released remain unclear. One hypothesis suggests that the IGF/binding protein complex acts as a circulating pool of growth factor which is released in response to local tissue injury, perhaps stimulated by changes in pH or by heparin release .
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