By John Lynn and Stephen R Bloom (Eds.)

A reference textual content at the surgical features of endocrine affliction drawing at the services of surgeons, physiologists, radiologists and expert endocrinologists. every one endocrine gland is roofed in different chapters outlining its body structure, pahtology, imaging and surgical administration

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Proceedings of the National Academy of Science of the USA, 83, 3510 (1986) 27. M. Hypophysiotropic regulation of adenohypophyseal adrenocorticotrophin secretion. Federation Proceedings, 44, 207-213 (1985) 28. , Bryant, K. A. Acute effects of corticotrophin and related peptides on carbohydrate and lipid metabolism. Annals of the New York Academy of Science, 131, 274-287, (1965) 29. Y. R. Effect of ACTH on FFA release and diglyceride content in rat adipose tissue. Annals of the New York Academy of Science, 131, 288-301, (1965) 30.

IGFBP-3, the largest of these molecules, binds the majority of circulating IGFs, the complex being retained within the circulation and levels are related to growth hormone status [51]. The mechanisms by which IGFs are bound to the binding proteins and how and under what circumstances they are released remain unclear. One hypothesis suggests that the IGF/binding protein complex acts as a circulating pool of growth factor which is released in response to local tissue injury, perhaps stimulated by changes in pH or by heparin release [52].

Brazeau, P. and Bohlen, P. Growth hormone releasing factor from a human pancreatic tumour that caused acromegaly. Science, 218, 585-587 (1982) 7. , Rivier, J. and Thorner, M. Primary structure of a growth hormone releasing factor from a human pancreatic islet cell rumour. Nature, 303, 532 (1982) 8. M. and Vale, W. Pattern of growth hormone releasing factor and somatostatin secretion into the hypophyseal - portal circulation of the rat. Science, 230, 461-463 (1985) 9. , Baird, A. N. GRF is a highly potent activator of adenylate cyclase in the normal human, bovine and rat pituitary: interaction with somatostatin.

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