By J. E. Alouf (auth.), Professor F. Gisou van der Goot (eds.)

Pore-forming pollutants are virulence elements produced through an exceptional number of pathogenic micro organism starting from the Gram-positive Staphylococcus aureus to the Gram-negative Helicobacter pylory. the hot reviews reviewed during this quantity describe the development that has been made in dissecting the several steps of the mode of motion of those proteins which usually comprise binding to express telephone floor receptors, oligomerization into ring like constructions and membrane perforation.

Show description

Read or Download Pore-Forming Toxins PDF

Similar nonfiction_9 books

Trace Gas Exchange in Forest Ecosystems

This quantity summarizes the present wisdom at the trade of hint gases among forests and the ambience with the limit that solely carbon and nitrogen compounds are integrated. For this objective the amount brings jointly and interconnects wisdom from assorted disciplines of organic and atmospheric sciences.

Recoding: Expansion of Decoding Rules Enriches Gene Expression

The dynamic nature of interpreting the data in messenger RNA was once unanticipated on the time the genetic code was once first deciphered. We now understand that either the that means of person codons and the framing of the readout approach might be changed through info in particular messenger RNAs. This publication describes this "Recoding" phenomenon, revealing the variety of an extra layer of data in mRNAs that serves to complement the expression of genes.

Observation of CP Violation in B± → DK± Decays

CP violation is a well-established phenomenon in particle physics, yet until eventually 2001 it used to be merely saw in kaons. within the final decade, a number of matter-antimatter asymmetries were saw in impartial B mesons in keeping with the expectancies of the traditional version of the vulnerable interplay. Direct CP violation is usually anticipated within the decay premiums of charged B+ mesons as opposed to that of B- mesons, although the best results are found in a decay that happens simply two times in 10 million decays.

The Vascular Endothelium I

This quantity bargains a accomplished evaluate of modern advances in learn at the vascular endothelium. It presents a ancient heritage and a consultant for destiny instructions in learn. This booklet includes 20 chapters by way of a various workforce of authors who've all made major contributions to the sector of study within the vascular endothelium.

Extra resources for Pore-Forming Toxins

Sample text

2 Relevance of Rafts in Other Infectious Processes A variety of other pore-forming toxins require, like aerolysin, an oligomerization step for channel formation to occur. Interestingly, amongst these, some also require molecules that have been identified in independent studies as raft components. , cholesterol-dependent toxins such as perfringolysin 0 require cholesterol.

1996; OLSON et al. 1999). The ct-helix to ~-sheet conformational change in PFO is therefore unprecedented among bacterial toxins, and this type of secondary structural change is in any case very rare, having been observed previously with only a very few proteins. The findings of SHEPARD et al. (1998) laid the groundwork for the subsequent discovery by SHATURSKY et al. (1999) of the presence of a second membranespanning ~-sheet. It was immediately obvious from the crystal structure of the soluble PFO monomer that residues K288-D311 (Fig.

49 1 Introduction Aeromonads are ubiquitous gram-negative bacteria found in aqueous environments. Some members of the genus are pathogenic for fish, reptiles and cows. In humans, Aeromonas infection is mainly associated with grastrointestinal diseases, but in immuno-compromised individuals infection can lead to septicemia and meningitis (AUSTIN et al. 1996). Aeromonas secretes a variety of virulence factors amongst which aerolysin is the best characterized. Using marker exchange mutagenesis, aero lysin was demonstrated to be required not only for the establishment but also for the subsequent maintenance of systemic infections associated with the Department of Biochemistry, Faculty of Sciences, University of Geneva, 30 Quai Ernest-Ansermet, 1211 Geneva, Switzerland 36 M.

Download PDF sample

Rated 4.91 of 5 – based on 43 votes