By Nils E. Billo (auth.), Pattisapu R. J. Gangadharam Ph.D., P. Anthony Jenkins Ph.D. (eds.)

Mycobacteria is split into volumes. the 1st quantity offers with the elemental biology of mycobacteria. With its emphasis at the cutting-edge outlook, this quantity comprises taxonomy and molecular biology of mycobacteria, sleek methods for detection of mycobacteria, and immunology and immunization opposed to tuberculosis. the second one quantity covers drug trestments for mycobacteria anad tuberculosis. It outlines tendencies of discovery and improvement of chemotherapy, ranging from the mid-50's to offer day makes use of of chemotherapy in treating AIDS, drug-resistant tuberculosis, and different non-tuberculosis mycobacterial diseases.

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Study 6 showed that twiceweekly PH was as good as daily PH. A. 5. Studies of intermittent regimens lasting at least 12 months; results in patients with pulmonary tuberculosis due to drug-sensitive organisms Study Place (date of start) No. 5MHSIM IH I No. of patients Slow Rapid All 71 79 123 117 104 79 106 105 176 170 178 168 165 233 83 90 25 24 107 110 112 102 119 109 130 107 101 107 109 92 82 97 76 95 87 93 95 80 94 100 100 99 b l00 b 100" 95 92 95 91 91 60 91 56 76 53 72 76 80 88 98 95 97 b 97 b 81 b 98 83 91 57 85 94 90 72 94 68 88 74 85 87 83 89 98 97 87 88 80 92 100 100 97 93 98 b 99 b 94b 96 88 93 75 Patients with H-resistant strains (%) Ref.

46,47 24 6 21 6 48,49 6 7 3 { { { 23 10 6 1" I" 16 16 8" 2" 3 5 3 6 11 0 8 2 { 1 { { SO { aZ2 = Z for first 2 months; Z. = Z for first 4 months; Z6 = Z for 6 months. " = follow-up for 18 months. "C = combined preparation of HRZ; S = H, Rand Z as separate preparations. 6. Low-Cost Regimens with an Initial Intensive Phase and a TH Continuation A major issue in the multicenter African studies was to economize on the use of R, then a very expensive drug, by using it only in an initial intensive phase.

An assessment of the emergence of H resistance using modem criteria of H resistance indicates that there were significantly more patients with H resistance during the first 4 months of treatment with ZH than with PH. 4. 9, the weights being the numbers of patients. The values fall roughly into three groups. H has the highest EBA. It is followed by M, P, and R, but it should be noted that the estimate for P is based on only four patients and is therefore very uncertain. Sand T have lower EBAs still; Z has the lowest of all, although it should be noted that Z has a steady slow bactericidal action throughout the first 14 days, unlike other drugs (98,108).

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