By Matthais Caestel
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Additional info for Molecular chaperones in health and disease
1987; Jorritsma et al. 1986; Kampinga et al. 1997; Mivechi and Li 1987; Raaphorst and Azzam 1983, and many more). Also, when Hsp70 or Hsp27 are transiently upregulated using inducible systems, no effect of radiosensitivity was found (unpublished data). Inversely, RNAimediated transient downregulation of Hsp70 was shown not to affect radiationinduced apoptosis (Ekedahl et al. 2003). Finally, although some stable cell lines overexpressing individual Hsp may become radiation resistant (Gehrmann et al.
J Biol Chem 272:31636–31640 Ohtsuka K, Hata M (2000) Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classiﬁcation and nomenclature. Cell Stress Chaperones 5:98–112 Parcellier A, Schmitt E, Gurbuxani S, Seigneurin-Berny D, Pance A, Chantome A, Plenchette S, Khochbin S, Solary E, Garrido C (2003) HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation. Mol Cell Biol 23:5790–5802 Parsell DA, Kowal AS, Lindquist S (1994) Saccharomyces cerevisiae hsp104 protein— puriﬁcation and characterization of ATP-induced structural changes.
Science 274:1715–1717 Botzler C, Issels R, Multhoff G (1996) Heat-shock protein 72 cell-surface expression on human lung carcinoma cells is associated with an increased sensitivity to lysis mediated by adherent natural killer cells. Cancer Immunol Immunother 43:226–230 Brown CR, Hong-Brown LQ, Doxsey SJ, Welch WJ (1996) Molecular chaperones and the centrosome. A role for HSP 73 in centrosomal repair following heat shock treatment. J Biol Chem 271:833–840 Bryantsev AL, Loktionova SA, Ilyinskaya OP, Tararak EM, Kampinga HH, Kabakov AE (2002) Distribution, phosphorylation, and activities of Hsp25 in heat-stressed H9c2 myoblasts: a functional link to cytoprotection.