By Bertrand Jordan (auth.), Bertrand Jordan (eds.)

Microarray expertise has made robust growth during the last decade, and there have additionally been major adjustments in program parts, from nucleic acids to proteomics and from learn to medical functions. This ebook presents a complete evaluate of microarrays in diagnostics and biomarker improvement, overlaying DNA, peptide, protein and tissue arrays. the focal point is on entities which are in real scientific use, or particularly shut, and on contemporary advancements, comparable to peptide and aptamer arrays. yet another subject is the miniaturisation in the direction of “nanoarrays”, that's anticipated to have nice strength in medical purposes. proper problems with bioinformatics and statistical research of array information are mentioned intimately, in addition to the limitations to the commercialisation of array-based checks and the vexing IP concerns concerned. hence, the booklet might be very worthwhile tor energetic array clients in addition to to novices trying to make the most suitable choice among diversified technologies.

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Extra resources for Microarrays in Diagnostics and Biomarker Development: Current and Future Applications

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There as well, some of these tests are being moved over to sequencing technology. 2 35 Scoring Copy Number Variation Another type of complex genotyping array has recently been assuming a growing role in clinical studies. Variously called “CGH array”, “CytoChip” or “CNV array”, this is designed to assay for the presence of copy number variation (hence CNV) in a patient’s DNA (Veltman 2006; Bejjani and Shaffer 2006). Such arrays contain thousands of probes distributed along the human genome and are hybridised with a mixture of normal human DNA (labelled with one fluorophore) and a patient’s DNA (labelled with a different fluorophore).

Html. Accessed 26 July 2011 Bejjani BA, Shaffer LG (2006) Application of array-based comparative genomic hybridization to clinical diagnostics. J Mol Diagn 8:528–553 Bell CJ, Dinwiddie DL, Miller NA, Hateley SL, Ganusova EE et al (2011) Carrier testing for severe childhood recessive diseases by next-generation sequencing. Sci Transl Med. com. Accessed 26 July 2011 Daly AK (2003) Pharmacogenetics of the major polymorphic metabolizing enzymes. gov/sites/GeneTests/. php. Accessed 26 July 2011 Government Accountability Office (2010) Direct-to-consumer genetic tests: misleading test results are further complicated by deceptive marketing and other questionable practices.

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