By C. C. Congdon, M. G. Hanna Jr. (auth.), H. Cottier, N. Odartchenko, R. Schindler, C. C. Congdon (eds.)

In the previous few years the research of germinal facilities of the lymphoid tissue has improved at an speeded up velocity. questions about their function and their value in immune responses that may no longer be replied, customarily as a result of tedmicallimitations, are almost immediately approached experimentally from many alternative instructions. Hypotheses, a few greater than part a century outdated, obtain renewed realization. at the present, participants of the Biology department, Oak Ridge nationwide Laboratory, united states, and of the Institute of Pathology, college of Bern, Switzerland, made up our minds to collect staff drawn to the sphere. The convention was once held in Bern, June 22-24, 1966, and integrated fifty-seven contributions which have been mentioned at size. the variety of curiosity prolonged from phylogenesis and anatomy to reports on telephone proliferation, immunohistochemistry, melanoma study and radiobiology. the purpose of this extensive assurance was once to mix all on hand info at the function of germinal facilities in immune responses in one package deal, rather than leaving it scattered round in experiences facing divergent immunological difficulties. This try is mirrored within the current ebook. a slightly huge house has been dedicated to the energetic discussions which the studies, the quantity of such a lot of which were voluntarily restricted. The discussions will not be said verbatim yet care has been taken to insure neutrality and objectivity within the worthy version of the shortened transcription. we have now been very lucky certainly, to have Drs.

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Additional info for Germinal Centers in Immune Responses: Proceedings of a Symposium held, at the University of Bern, Switzerland, June 22–24, 1966

Sample text

Thus we consider the central lymphoid tissues, i. , the thymus and bursa or bursa equivalent, of greatest importance in direction of cellular differentiation and peripheral lymphoid tissues important in execution of immune response. These observations further indicate that there is horizontal compartmentalization into thymic dependent cells and functions and bursal (or bursal equivalent) dependent cells and function. Viewing the lymphoid tissue in this perspective provides incisive experimental approaches and a new view of many clinical problems.

GOOD and J. FINSTAD Fig. 11 b Fig. 11 c Phylogenetic Development of Germinal Centers 21 such fetuses, a fact supported by the absence of y-globulins in their serum and absence of plasma cells and germinal centers in their peripheral lymphoid tissues at birth. Peyer's patches in both man and bovine appear to undergo involution beginning shortly after puberty (CARLENS, 1928; CaRNEs, 1965). None of the fishes, amphibians, or reptiles we have studied possess either germinal center development in the peripheral lymphoid tissues or Peyer's patch type of central lymphoid tissue development.

Our impression is, therefore, that the thymus, besides the bursa, may playa role in the development of germinal centers. I would like to have Dr. GOOD'S comment on this subject. Good: The contribution of Dr. JANKOVIC points out an important question, namely: do the cells of the thymic system participate in the development of the bursa? Certainly the thymus develops earlier than the bursa. The best evidence supporting the concept that there can be a complete dissociation of these two populations comes from clinical considerations which will be discussed in another session.

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