By J. H. J. M. Van Krieken, M. A. Hoeve (auth.), Prof Dr. med Wolfgang Fischbach (eds.)
Gastrointestinal lymphomas have attracted expanding curiosity during the last few years and are a subject matter characterised via extensive and ongoing task. Insights of their pathogenesis and organic habit have improved impressively. even though, this elevated figuring out has additionally raised many new questions. specialists from world wide got here jointly to interchange their reviews and to debate new thoughts at a world Symposium in Würzburg, Germany, in 1998. This ebook summarizes the presentations.
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Additional info for Gastrointestinal Lymphoma: Future Perspectives
Felis colonises the stomach of the mouse in large numbers . The H. felis-infected mouse became the most used animal model for the testing of antimicrobial compounds and for vaccine development as, at that stage, no strains of H. pylori colonised the rodent gastric mucosa in large numbers [2, 14]. The First Demonstration of Lymphomas in H. felis-Infected Mice We were interested in the long-term consequences of H. felis infection in the mouse model and therefore followed infection in BALB/c mice for up to two Fig.
Am J Pathol132:1-5 35. Stein H, Dienemann D, Sperling M, Zeitz M, Riecken EO (1988) Identification of a Tcell lymphoma category derived from intestinal mucosa-associated T-cells. Lancet ii: 1053-1 054 36. Weisenburger DD, Armitage JO (1996) Mantle cell lymphoma - an entity comes of age. Blood 87:4483-4494 37. Whitehead R (1968) Primary lymphadenopathy complicating idiopathic steatorrhoea. Gut 9:569-575 38. Wright DH, Jones DB, Clark H, Mead GM, Hodges E, Howell WM (1991) Is adult-onset coeliac disease due to a low-grade lymphoma of intraepithelial T lymphocytes?
MALTNHL cells characteristically invade and colonize pre-existing lymphoid follicles. This ultimately results in the splitting-up of germinal centers, whereby clusters of centro blasts can be found within the small cell malignant lymphoid infiltrate. The presence of macrophages with apoptotic debris may disclose the germinal center nature of the blasts. Also demonstration of follicular dendritic networks using immunohistochemistry is very helpful, and this staining should not be ignored when analyzing histological grade in gastric MALT-NHL.