By Elias J. Corey, Laszlo Kurti

Written via world-renowned and best-selling specialists, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis bargains an authoritative and complete evaluation of the field’s growth; the approaches and instruments for key formations; destiny improvement for advanced, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and necessary examples of multi-step syntheses. using a color-coded scheme to demonstrate chemical alterations, Enantioselective Chemical Synthesis offers transparent clarification and counsel via important asymmetrical syntheses and perception into the following steps for the sphere. Researchers, execs, and lecturers will take advantage of this important, thorough, and precise source.

  • In half I, the authors current in actual fact, comprehensively and concisely the main precious enantioselective approaches to be had to artificial chemists.
  • Part II offers an in depth dialogue of the main logical how one can observe those new enantioselective how to the making plans of syntheses of stereochemically advanced molecules. This hitherto ignored quarter is vital for the development of enantioselective synthesis to a extra rational and strong point.
  • Part III describes intimately many response sequences that have been used effectively for the development of a large choice of advanced aim molecules
  • Clearly explains stereochemical synthesis in concept and practice
  • Provides a handy gizmo field for scientists wishing to appreciate and observe chiral chemical synthesis
  • Describes nearly 50 actual existence examples of uneven synthesis in perform and examines how the chiral facilities have been brought at key man made stages

Show description

Read Online or Download Enantioselective Chemical Synthesis. Methods, Logic, and Practice PDF

Similar allied health professions books

Enhancing Food Safety: The Role of the Food and Drug Administration

Contemporary outbreaks of health problems traced to infected sprouts and lettuce illustrate the holes that exist within the approach for tracking difficulties and fighting foodborne illnesses. even though it isn't really completely liable for making sure the protection of the nation's nutrition offer, the U. S. nutrition and Drug management (FDA) oversees tracking and intervention for eighty percentage of the nutrition provide.

The Multisensory Handbook: A guide for children and adults with sensory learning disabilities

Do you help a baby or grownup with sensory perceptual concerns or cognitive impairment? for individuals with not easy sensory and cognitive stipulations, way of life can turn into so unpredictable and chaotic that through the years, loss of engagement can frequently result in a country of discovered helplessness. during this insightful textual content, Paul Pagliano indicates how ‘learned helplessness’ might be reworked into realized optimism via multisensory stimulation, and explains how a programme of aid might be designed and modulated to compare the person’s wishes, pursuits and talents.

Extra info for Enantioselective Chemical Synthesis. Methods, Logic, and Practice

Sample text

Catal. 1984, 22, 283-287. Cobley, C. J. & Henschke, J. P. Enantioselective hydrogenation of imines using a diverse library of ruthenium dichloride(diphosphine)(diamine) precatalysts. Adv. Synth. Catal. 2003, 345, 195-201. Xiao, D. & Zhang, X. Highly enantioselective hydrogenation of acyclic imines catalyzed by Ir-f-binaphane complexes. Angew. , Int. Ed. 2001, 40, 3425-3428. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. , Amii, H. & Uneyama, K. Pd-catalyzed asymmetric hydrogenation of alpha-fluorinated iminoesters in fluorinated alcohol: a new and catalytic enantioselective synthesis of fluoro alpha-amino acid derivatives.

Behrens, C. , Lee, A. W. , Martin, V. , Viti, S. , Walker, F. J. & Woodard, S. S. Stereo and regioselective openings of chiral 2,3-epoxy alcohols. Versatile routes to optically pure natural products and drugs. Unusual kinetic resolutions. Pure Appl. Chem. 1983, 55, 589-604; (c) Hanson, R. M. The synthetic methodology of nonracemic glycidol and related 2,3-epoxy alcohols. Chem. Rev. 1991, 91, 437-476; (d) Pena, P. C. A. & Roberts, S. M. The chemistry of epoxy alcohols. Curr. Org. Chem. 2003, 7, 555-571.

Reding, M. T. & Buchwald, S. L. Highly Enantioselective Imine Hydrosilylation Using (S,S)Ethylenebis(η5-tetrahydroindenyl)titanium Difluoride. J. Am. Chem. Soc. 1996, 118, 6784-6785; (b) Kobayashi, S. & Ishitani, H. Catalytic Enantioselective Addition to Imines. Chem. Rev. 1999, 99, 10691094; (c) Nishiyama, H. & Itoh, K. Asymmetric Hydrosilylation and Related reactions in Catal. Asymmetric Synth. -F. & Bette, V. Chemo- and enantioselective hydrosilylation of carbonyl and imino groups. An emphasis on nontraditional catalyst systems.

Download PDF sample

Rated 4.44 of 5 – based on 14 votes