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2010). Although pluripotent stem cells have been derived from mouse, rat, monkey, pig and rabbit by reprogramming differentiated cells back to the ground state, only mouse and rat iPSC have shown GLT, although human iPSC can not be tested for obvious ethical reasons. The continued study of mouse ESC therefore remains the gold standard by which other pluripotent stem cell types should be measured. 6. K. F are members of the Oxford Stem Cell Institute. 7. C. & Føgh, J. (1984). Pluripotent embryonal carcinoma clones derived from the human Embryonic Stem Cells and the Capture of Pluripotency 21 teratocarcinoma cell line Tera-2.

Et al; (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, Vol. 131, pp. 861-872. , (2005). Derivation of germ-line competent embryonic stem cell lines from preblastocyst mouse embryos. Proc. Natl. Acad. Sci. USA, Vol. 102, pp. 8239-8244. L. , (2007). New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature, Vol. 448, pp. 196-199. R. , (1990). Targeted disruption of the murine Int-1 protooncogene resulting in severe abnormalities in midbrain and cerebellar development.

S 3-4, pp. 76-81. ; Huettner, J. E. & Gottlieb, D. I. (1995). Embryonic stem cells express neuronal properties in vitro. Developmental Biology, Vol. 168, pp. 342—357. H. & Robertson, E. (1984). Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature, Vol. 309(5965), pp. 255-6. A. , (2007). Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature Vol. 448, pp. 191-195. A. L. (1997). The origin and efficient derivation of embryonic stem cells in the mouse.

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