Chapter 1 The Metabolism of C19 Steroids via person Tissues (pages 236–243): Leo T. Samuels
Chapter 2 In vivo Metabolism of C19 Steroids (pages 244–250): Frank Ungar and Ralph I. Dorfman
Chapter three Is Dehydroisoandrosterone remoted from Urine Extracts an unique 17?Ketosteroid or a made of Chemical Degradation? (pages 251–273): E. Dingemanse
Chapter four The impact of Androgens at the Urinary Excretion of Steroid Alcohols and ?strogens (pages 274–285): Lewis L. Engel, Marion Lance, Gladys Ekman, Katherine H. Spaulding, Priscilla Carter and Ira T. Nathanson
Chapter five Excretion of Steroids in a Case of Interstitial mobile Tumour of the Testis (pages 286–290): Eleanor H. Venning
Chapter 6 Metabolism of impartial C21 and C19 Steroids (pages 291–308): Ralph I. Dorfman
Chapter 7 Progesterone Metabolism—A evaluation (pages 309–326): William H. Pearlman
Chapter eight The Metabolism of Progesterone in Goats (pages 327–328): R. J. Boscott
Chapter nine The Separation of Urinary Cortical Steroids (pages 329–333): R. J. Boscott
Chapter 10 The middleman Metabolism of Progesterone in Human topics (pages 334–346): Ian F. Sommerville
Chapter eleven The Metabolism of Progesterone and similar Compounds (pages 347–353): Ralph I. Dorfman, Frank Ungar, Paul Wgnos, Robert M. Stecher and Norman Shumway
Chapter 12 Metabolic experiences on Orally Administered Progesterone (pages 354–358): Eleanor H. Venning
Chapter thirteen Blood Progesterone in being pregnant (pages 359–365): C. J. O. R. Morris
Chapter 14 On attainable Relationships among the Metabolic Breakdown of Progesterone and its organic task (pages 366–374): H. S. Guterman
Chapter 15 11?Oxygenating Enzyme process (pages 375–380): Ralph I. Dorfman and Mika Hayano
Chapter sixteen The Metabolism of Steroid Hormones in people (pages 381–417): okay. Dobriner and S. Lieberman
Chapter 17 The impression of Corticosteroids on Carbohydrate and Electrolyte Metabolism in vitro (pages 418–422): F. Verzar
Chapter 18 Chairman's last feedback (pages 423–424): R. ok. Callow

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Extra resources for Ciba Foundation Symposium - Metabolic Breakdown of Steroids (Book II on Colloquia on Endocrinology), Volume II

Example text

The figure shows the 17-ketosteroid pattern of a normal woman before and after administration of dehydroisoandrosterone acetate. Beside this we see the 17-ketosteroid pattern of a girl with an adrenal cortical adenoma. If the urine of the latter has been directly hydrolysed with hydrochloric acid, the amount of rdehydroisoandrosterone found would in fact have exceeded 150 mg. per 24 hr. Why, in spite of this, is the androsterone and aetiocholanolone content of such urine so extremely low? Mason’s conclusion was that there is a disturbance of 17-ketosteroid metabolism in such cases.

For this reason we heat the urine with benzene a t pH 7 (the other conditions being the same) before carrying out the acid hydrolysis. Not until this has been done do we add 1/10 vol. of conc. HC1 to the urine residue and extract further in the usual way. For the chromatographic analysis we took an aliquot of each of these two extracts, mixed them and proceeded in the usual way. The diagram then revealed a maximum I1 between maxima I and 111. However, when the extraction was done directly in acid medium in the ordinary way, this maximum I1 did not appear and the value for dehydroisoandrosterone was increased by an amount corresponding t o that of Compound I1 (Fig.

But this proved to be impossible; the compound was extracted only at higher temperatures. This led to the conclusion that i-androstanolone is in all probability present in combination, presumably esterified, in native urine. We did in fact succeed (once more by means of chromatographic analysis) in isolating i-androstanolone in the form of the sodium salt of its sulphate ester from the butanol extract. i-Androstanolone occurs in native urine in the form shown in Fig. 10. Heating of this ester in water or in alkaline solution is sufficient to cause partial saponification.

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