By Anthony N. Laskovski
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Electrospun Water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration. Biomacromolecules 2008; 9: 349-354. 2 Influence of the Chemical Structure and Physicochemical Properties of Chitin- and Chitosan-Based Materials on Their Biomedical Activity Jolanta Kumirska1, Mirko X. Weinhold2, Małgorzata Czerwicka1, Zbigniew Kaczyński1, Anna Bychowska1, Krzysztof Brzozowski1, Jorg Thöming2, and Piotr Stepnowski1 1Faculty of Chemistry, University of Gdansk, Sobieskiego 18/19, PL-80-952 Gdansk, 2UFT - Centre for Environmental Research and Sustainable Technology, University of Bremen, Leobener Straße UFT, D-28359 Bremen, 1Poland 2Germany 1.
Tashiro T. Antibacterial and bacterium adsorbing macromolecules. Macromol Mat Eng 2001; 286: 63-87. Thomas V, Yallapu M, Mohan SB, Bajpai SK. Fabrication, characterization of chitosan/nanosilver film and its potential antibacterial application. J Biomat Sci Polym Ed 2009; 20: 2129-2144. Tsao CT, Chang CH, Lin YY, Wu MF, Wang JL, Young TH, Han JL, Hsieh KH. Evaluation of chitosan/γ-poly(glutamic acid) polyelectrolyte complex for wound dressing materials. 034 Turner TD, Schmidt RJ, Harding KG. ).
They found that LMWC (21 and 46 kDa) and also smaller oligosaccharides could activate the intestinal immune system of animals, thus preventing tumour growth. But no antitumour effect was observed after the oral administration of chitosan samples, even of low molecular weight (46 kDa). The same authors confirmed that high molecular weight chitosan (650 kDa) prevents the adverse reactions of some cancer chemotherapeutic drugs. Qin et al. also tested the antitumour activity of LMWC against sarcoma 180, but they came to the opposite conclusions.