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C , Igerscheiner, W. (1956). 'Psychosis and allergy: Experimental approach'. Amer. J. Psychiat. 112, 873-877. Friedhoff, A. , Hollister, L. E. (1966). 'Comparison of the metabolism of 3-4 dimethoxyphenylethylamine and mescaline in humans'. Biochem. Pharm. 15, 269-273. Friedhoff, A. , Van Winkle, E. (1962). 'Isolation and characterisation of a com­ pound from the urine of schizophrenics'. Nature, 194, 897-898. , Beck, R. A. (1965). 'Amplitude analysis of the electroencephalogram. Review of the information obtained with the integrating method'.

C , Beck, R. , Neiss, E. S. (1967). 'Etiology of the stimulant nature of the schizophrenias'. In Ch. 16 in Recent Advances in Biological Psychiatry, Vol. IX (J. ). New York, Pergamon Press, pp. 241-249. Price, J. , Brown, R. , Peters, H. A. (1959). 'Tryptophan metabolism in porphyria, schizophrenia and a variety of neurologic and psychiatric disorders'. Neurology, 9, 456-468. Seeman, P. M. (1966). 'Membrane stabilisation by drugs: tranquilizers, steroids and anaesthetics'. Int. Rev. Neurobiol. 9, 146-222.

To be unreliable. The enzyme concerned— tryptophane pyrrolase—has a very high degree of adaptability and is 40 Biological Psychiatry affected by other vitamin deficiencies besides pyridoxine as well as by cortisone. Furthermore, they found a very wide variation both between and within subjects in both groups in the excretion levels of xanthurenic acid and 3-hydroxy kynurenine. They thus explain the previous results on the ground of the operation of uncontrolled factors such as stress and vitamin deficiencies.

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