By Douglas T. Carrell, Peter N. Schlegel, Catherine Racowsky, Luca Gianaroli

Now in its fourth quantity, the Biennial evaluate of Infertility brings jointly the main up to date learn and medical details on female and male infertility, rising assisted reproductive ideas and evolving controversies in reproductive drugs. a powerful panel of members offers state-of-the-art info in a transparent and well-balanced demeanour. quantity four discusses scorching subject matters in modern reproductive drugs, together with stem phone applied sciences for male infertility, the present kingdom of ovarian tissue cryopreservation and time-lapse video microscopy of embryos. The improved part on controversies makes it possible for point/counterpoint dialogue among specialists with differing evaluations on themes like eSET and the use and position of supplements in IVF cycles. Created to supply an ongoing appraisal of present wisdom, the Biennial overview of Infertility stimulates communique among all clinicians and researchers operating to aid unravel their infertility.

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Schover LR, Brey K, Lichtin A, Lipshultz LI, Jeha S. Knowledge and experience regarding cancer, infertility, and sperm banking in younger male survivors. J Clin Oncol. 2002;20(7):1880–9. 37. Hsiao W, Stahl PJ, Osterberg EC, Nejat E, Palermo GD, Rosenwaks Z, Schlegel PN. Successful treatment of postchemotherapy azoospermia with microsurgical testicular sperm extraction: the Weill Cornell experience. J Clin Oncol. 2011;29(12):1607–11. 38. Paniagua R, Nistal M. Morphological and histometric study of human spermatogonia from birth to the onset of puberty.

2012; 33(2):181–9. Slade P, O’Neill C, Simpson AJ, Lashen H. The relationship between perceived stigma, disclosure patterns, support and distress in new attendees at an infertility clinic. Hum Reprod. 2007;22(8):2309–17. Wu AK, Elliott P, Katz PP, Smith JF. Time costs of fertility care: the hidden hardship of building a family. Fertil Steril. 2013;99(7):2025–30. Jensen TK, Jacobsen R, Christensen K, Nielsen NC, Bostofte E. Good semen quality and life expectancy: a cohort study of 43,277 men. Am J Epidemiol.

Challenge: Malignant Contamination in Testicular Biopsy A testicular biopsy obtained from the testis of a cancer patient could harbor occult malignant cells, especially for patients with leukemia. Indeed, Kim and colleagues [110] reported that 20 % of boys with acute lymphocytic anemia had malignant cells in their testicular tissue prior to the initiation of oncologic treatment. 1 Human spermatogonial stem cell culture [101] [97] [98] [95] [96] [100] [102] [42] [43] Ref. [99] 24 H. Valli et al.

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