By Ricardo Azziz (auth.), Ricardo Azziz MD, MPH, MBA, John E. Nestler MD, Didier Dewailly MD (eds.)

The box of androgen extra problems has complex considerably because the unique booklet of this ebook. The Androgen extra Society (AES) used to be based to collect investigators within the box. a greater figuring out of the screening, development, and molecular genetics of nonclassic adrenal hyperplasia (NCAH) has more desirable the medical care and diagnostic accuracy of those sufferers. New standards for the prognosis of the polycystic ovary syndrome (PCOS) have been proposed in Rotterdam, standards that experience ended in controversy and, with a bit of luck, initiation of latest stories. The organization of insulin resistance with PCOS has been bolstered, and the position of metformin in tre- ing the infertility of the PCOS has been demonstrated. hazards for diabetes and, extra cont- versially, heart problems in ladies with PCOS have acquired sizeable research. Our knowing of the epidemiology and financial impression of those issues has multiplied, emphasizing their serious value. those are yet a number of highlights of the way the terrain has replaced in a comparatively short time period. in accordance with those advances, the identify of this publication has been revised to mirror the transforming into significance of PCOS because the such a lot generic androgen extra affliction in girls, and arguably, because the person who may need the main severe adversarial outcomes for normal overall healthiness. There are fewer chapters to supply a extra concentrated elucidation of the realm. a number of chapters have been penned by means of new (and younger) authors who're engaging in state-of-the-art study within the field.

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Compound heterozygous mutations of cytochrome P450 oxidoreductase gene (POR) in two patients with Antley-Bixler syndrome. Am J Med Genet 2004;128A:333–339. 39. Fukami M, Horikawa R, Nagai T, et al. POR (P450 oxidoreductase) mutations and Antley-Bixler syndrome with abnormal genitalia and/or impaired steroidogenesis: molecular and clinical studies in 10 patients. J Clin Endocrinol Metab 2005;90:414–426. 40. Huang N, Pandey AV, Agrawal V, et al. Diversity and function of mutations in P450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis.

J Clin Endocrinol Metab 1983;57:356–359. 101. Barbieri RL, Makris A, Ryan KJ. Effects of insulin on steroidogenesis in cultured porcine ovarian theca. Fertil Steril 1983;40:237–241. 102. Barbieri RL, Makris A, Ryan KJ. Insulin stimulates androgen accumulation in incubations of human ovarian stroma and theca. Obstet Gynecol 1984;64(Suppl):73S–80S. 103. Barbieri RL, Makris A, Randall RW, et al. Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism.

Ehrmann DA, Barnes RB, Rosenfield RL. Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Endocr Rev 1995;16:322–353. 78. Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanisms and implications for pathogenesis. Endocr Rev 1997;18:774–800. 79. Bollag G, Roth R, Beaudoin J, Mochley-Rosen D, Koshland D Jr. Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.

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