By Azoulay E., Avignant Jean

Azoulay E., Avignant J. Mathematiques three. examine (MGH, 1984)(fr)(ISBN 2704210888)

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Air containing more than 3% CO2 was reported to be hazardous to humans; 6–10% CO2 is very dangerous. Such danger should be kept in mind, and laboratories should be ventilated during such experiments. The consumption of the liquid CO2 is rapid especially for COT at very low temperatures; this means that more cost for liquid CO2 is needed for lower oven temperatures. 2 Structural schema of cryogenic oven trapping (COT) GC. Liquid nitrogen is vaporized in the GC oven for cooling under the control of a microcomputer.

Robertson and Drummer [22] reported that nitrobenzodiazepine drugs were metabolized to 7-amino reduced forms by enteric bacteria and that such reducing reaction could not be suppressed by adding NaF. The author et al. 1. 55 * Stored at 4° C. The reductive reaction for nitrazepam proceeds upon storage of specimens at 4° C, but such reaction can be completely suppressed at –20° C [22]. Clozapine, an antipsychotic drug, is easily metabolized antemortem to an N-oxide form, which accumulates in blood of living subjects; the metabolite can be conversely reduced to form the precursor clozapine in a cadaver and in blood stored in a vial by the action of bacteria.

Skeletal muscle Garriott [31] and the author et al. [3] clarified that drug concentrations in the skeletal muscle well reflected those in blood. 0. Therefore, when blood cannot be sampled or contamination of blood is suspected, alcohol concentrations in the skeletal muscle can be an indicator for intoxication degree and estimation of the quantity ingested [18, 32]. Although the concentration equality observed for alcohol in the skeletal muscle is not the case for other drugs [33], the drug concentration in the muscle seems very helpful for judgement of poisoning and its degree.

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