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Extra resources for Acute Leukemias: Prognostic Factors and Treatment Strategies

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Blick M, Westin E, Gutterman J, Wong Staal F, Gallo R, McCredie K, Keating, Murphy E (1984) Oncogene expression in human leukemia. Blood 64:1234--1239 11. McClain (1984) Expression of oncogenes in human leukemias. Cancer Res 44:5382-5389 12. Varmus HE (1984) The molecular genetics of cellular oncogenes. Annu Rev Genet 18:533612 13. Slamon DJ, deKernion JB, Verma 1M, Cline MJ (1984) Expression of cellular oncogenes in human malignancies. Science 224:256--262 14. Sakurai M, Sandberg AA (1973) Prognosis in acute myeloblastic leukemia: chromosomal correlation.

In addition, we compared the cytochemical 25 patterns described earlier with the immunophenotypes determined in our study (see Thiel et aI, this volume). There is a highly significant correlation between focal AcP and the T and, to a lesser degree, the pre-T phenotypes, compared with only a small proportion of C/pB and O-ALL disclosing this pattern of AcP reaction. The most specific, but least sensitive technique is the DAP IV method: With only one exception, it was exclusively positive in the T and preT-ALL cases.

This applies equally to acute nonlymphocytic leukemia (ANLL) and acute lymphoblastic leukemia (ALL). The present paper will deal with a succinct evaluation and clarification of the relative importance of established cytogenetic changes in the prognostic aspects of acute leukemia. The chromosomal (karyotypic, cytogenetic) abnormalities concerned with the prognostic aspects of acute leukemia can be classified as follows, in the order of their relative importance: 1. Specific (primary) karyotypic change 2.

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